.. , .. . ( ). . 2005 .


10.

, , , , .

. , , : , , [52]. , , , .

, , , , , , 5-, , . In vitro ( ) [18, 24, 239243]. , , : >, >>>, >- [244]. in vitro in vivo. , , G [24, 239].

.

, 1 ( 1 14 ). I , , , , II III .

10 2030 . - 30 .

, . .

, , - . , . (, ) . , (200 ) 87%- [247].

, , 1980- , in vivo , () B. burgdorferi sensu stricto [18, 248, 249, 271]. .

- , () , . , , .

. in vivo : , [250], - OspA- [251, 252], OspC [253], OspB, OspF, OspE [18, 249, 254]. . OspA Osp.

, OspA, B. burgdorferi sensu lato [255]. OspA -, , , - - . , , . , OspA , [256]. , [249, 256, 257].

Pasteur Merieux Connaught Smith-Kline-Beecham OspA-. LYMErix, SmithKline-Beecham Biologicals, OspA, 21 1998 Food and Drug Administration (FDA) () 16 . , .

, , 17 , , OspA [258]. 80%- 15 70 .

, 1998 2000 , 905 1 400 000 . OspA. , , , ( ), , . 7,4% , , [249, 259].

, OspA , [260, 261]. in vivo , OspA- . OspA , , OspA [262, 263]. OspA - B. burgdorferi sensu lato OspA . , OspA . burgdorferi sensu stricto, B. afzelii B. garinii [264]. .

OspA , . spC [249, 253] , ( (DbpA), ), [265, 266].

, OspC . , -OspC - [267]. OspC B. burgdorferi sensu lato, OspA [268], , , , [269].

OspA / OspC, . B. burgdorferi sensu lato.

OspC DbpA OspB [254], 35 37 [270] 66 [200], in vivo [272, 273]. [249], , - 1%.

, B. burgdorferi sensu lato (B. burgdorferi sensu stricto, B. afzelii, B. garinii) . - . , , , .


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